Biotin Anti-Human CD58 Antibody [clone TS2/9.1]

Background:
CD58, also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is expressed on both hematopoietic and non-hematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of it's cognate ligand, CD2, on the T cell surface.

Research Area: Cancer, Immunology

Synonyms:
Lymphocyte function-associated antigen 3, CD58, Ag3, Surface glycoprotein LFA-3, LFA3
Swissprot: P19256

Buffer: PBS with 0.05% Proclin300, 1% BSA

Concentration: 0.5 mg/mL

Storage:
Store at 2~8°C. Do not freeze.