BLC/BCA-1/CXCL13/B lymphocyte chemoattractant Polyclonal, anti-human, dog

Description: Burkitt’s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B lymphocyte chemo-attractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B cell migration into splenic and Peyer’s patch follicles. BLC expression in Peyer’s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation.Localization: secretedDilution: 10-50Positive Control: brain, breast tumorHIER: citrate pH6.0 or EDTA pH8.0Status: RUO