BLK (clone 9D10D1), anti-human
€443.00
In stock
SKU
252665
Catalog Nr.: 252665
Size: 0.1 ml
Isotype: Mouse IgG2a
Applications: IHC
Size: 0.1 ml
Isotype: Mouse IgG2a
Applications: IHC
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Immune System
Description:
BLK (B lymphoid tyrosine kinase) is a 505-amino acid protein (~56KDa), belongs to the Src non-receptor tyrosine kinases family. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Alternate Names: Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK
Application Notes: IHC: 1:200-1:1000
Accession No.: P51451
Antigen: Purified recombinant fragment of BLK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Immune System
Description:
BLK (B lymphoid tyrosine kinase) is a 505-amino acid protein (~56KDa), belongs to the Src non-receptor tyrosine kinases family. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Alternate Names: Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK
Application Notes: IHC: 1:200-1:1000
Accession No.: P51451
Antigen: Purified recombinant fragment of BLK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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