BLK (phospho-Y389) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64159
Background:
Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development. Activation of B cells by various ligands is accompanied by activation of Blk. It has been suggested that Blk is involved in the control of B cell differentiation and proliferation. Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis. Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.
Alternative Name:
Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK
Application Dilution: WB: 1:500~1:1000
Specificity: BLK (phospho-Y389) polyclonal antibody detects endogenous levels of BLK protein only when phosphorylated at Tyr389 .
Immunogen:
Synthetic phosphopeptide derived from human BLK around the phosphorylation site of Tyrosine389.
MW: ~ 57 kDa
Swis Prot.: P51451
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development. Activation of B cells by various ligands is accompanied by activation of Blk. It has been suggested that Blk is involved in the control of B cell differentiation and proliferation. Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis. Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.
Alternative Name:
Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK
Application Dilution: WB: 1:500~1:1000
Specificity: BLK (phospho-Y389) polyclonal antibody detects endogenous levels of BLK protein only when phosphorylated at Tyr389 .
Immunogen:
Synthetic phosphopeptide derived from human BLK around the phosphorylation site of Tyrosine389.
MW: ~ 57 kDa
Swis Prot.: P51451
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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