BLM Peptide
€100.00
In stock
SKU
350521
Protein Family: Enzymes
Pathway and Disease: Cancers, Replication and Repair
Alternate Names: Bloom syndrome protein; RecQ protein-like 3; DNA helicase RecQ-like type 2; BLM; RECQ2; RECQL3
Accession No.: P54132, NP_000048
Description:
BLM, a helicase protein from the RecQ subfamily, participates in DNA replication and repair with a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. BLM is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BLM are the cause of bloom syndrome, characterized by growth deficiency, skin pigmentation disorders, predisposition to malignancy and chromosomal instability.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2154.3 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200159 is selected from a sequence within the N-term region of human BLM. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C86H144N32O31S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease: Cancers, Replication and Repair
Alternate Names: Bloom syndrome protein; RecQ protein-like 3; DNA helicase RecQ-like type 2; BLM; RECQ2; RECQL3
Accession No.: P54132, NP_000048
Description:
BLM, a helicase protein from the RecQ subfamily, participates in DNA replication and repair with a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. BLM is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BLM are the cause of bloom syndrome, characterized by growth deficiency, skin pigmentation disorders, predisposition to malignancy and chromosomal instability.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2154.3 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200159 is selected from a sequence within the N-term region of human BLM. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C86H144N32O31S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
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