Brachyury/Bry/T-Antibody [clone A4], anti-human, mouse, rat

Description: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.Localization: nucleusDilution: 25-100Positive Control: Human cervical cancer and rectum cancer tissues, HeLa cells; Jurkat and Raji cell lysatesHIER: citrate pH6.0 or EDTA pH8.0Status: RUO