BRCA1 (phospho-S1423) polyclonal, anti-human, rat
€328.00
In stock
SKU
BS4756
Background:
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Alternative Name:
Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53
Application Dilution: IHC: 1:50~1:200
Specificity: p-BRCA1 (S1423) polyclonal antibody detects endogenous levels of BRCA1 protein only when phosphorylated at Ser1423.
Immunogen:
Synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Serine 1423.
MW: ~ 200 kDa
Swis Prot.: P38398
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Alternative Name:
Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53
Application Dilution: IHC: 1:50~1:200
Specificity: p-BRCA1 (S1423) polyclonal antibody detects endogenous levels of BRCA1 protein only when phosphorylated at Ser1423.
Immunogen:
Synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Serine 1423.
MW: ~ 200 kDa
Swis Prot.: P38398
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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