BRCA1 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Ubiquitins

Pathway and Disease: Cancers, Folding, Sorting and Degradation, Replication and Repair, Signal Transduction

Description:
Breast cancer type 1 susceptibility protein (BRCA1) is an E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. Defects in BRCA1 are a cause of susceptibility to breast cancer (BC).

Alternate Names: BRCA1, Breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53

Application Notes: E: 1:500-1:1,000; IHC: 1:100-1:500

Accession No.: P38398

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BRCA1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.