BTK (clone 7F12H4), anti-human, monkey
€363.00
In stock
SKU
252705
Catalog Nr.: 252705
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections.
Alternate Names: BTK, Tyrosine-protein kinase BTK, Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, AGMX1, ATK, BPK
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: Q06187
Antigen: Purified recombinant fragment of BTK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections.
Alternate Names: BTK, Tyrosine-protein kinase BTK, Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, AGMX1, ATK, BPK
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: Q06187
Antigen: Purified recombinant fragment of BTK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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