C5 Complement (clone 12F3), anti-human

Protein Family: Enzymes, CAM ligands, Cellular Adhesion Molecules

Pathway and Disease: Immune System, Cell Communication

Description:
C5 is part of the membrane attack complex (MAC) of the complement system. C5 is split into C5a and C5b by the C5 convertases from the classical and the alternative complement pathway and the C5b fragment initiates the assembly of the terminal MAC (C5b-C9). The molecular mass of C5 is 190 kDa. This antibody is specific for human C5. No reaction is seen with plasma from patients deficient in C5.

Alternate Names: Complement component C5, Complement component 5 preprotein

Application Notes: Product Cat. No. 250301 reacts strongly with C5 from normal human plasma and does not with plasma from patients deficient in C5, when tested in sandwich ELISA in combination with a polyclonal antibody against C5. Product Cat. No. 250301 reacts in Western blot with C5 in normal human plasma in nonreduced form only (PEG precipitated C5), but no reaction is seen with plasma from C5-deficient patients. E: 1:6,000; WB: 1:500

Accession No.: NP_001726

Antigen: C5 isolated from human plasma

Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.