C5a Complement polyclonal, anti-human, mouse, rat, chimpanzee

Protein Family: Enzymes; CAM ligands; Cellular Adhesion Molecules

Pathway and Disease: Immune System; Cell Communication

Description:
C5 is part of the membrane attack complex (MAC) of the complement system. C5 is split into C5a and C5b by the C5 convertases from the classical and the alternative complement pathway and the C5b fragment initiates the assembly of the terminal MAC (C5b-C9). The molecular mass of C5 is 190 kDa. C5a is later cleaved into C5 anaphylatoxin, a mediator of local inflammation, and C5a'.

Alternate Names: Complement component C5, Complement component 5 preprotein, C5a complement, C5 alpha chain, C5a anaphylatoxin, C5a', C5 alpha' chain

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: NP_001726

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human C5a Complement.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Yamamoto M et al. 2016. Mol Carcinog. 56(2): 478-488. PMID 27253992.
[2] Ji M et al. 2016. PLoS One. 11(9) e0161867. PMID 27583546.
[3] Phieler J et al. 2013 J Immunol. 181(8): 4367-74. PMID 24043887.
[4] Byrne R et al. 2012. PLoS ONE 7(4):e35194. PMID 22529989.