Protein Family: Cytoskeleton Proteins
Pathway and Disease: Signaling Molecules and Interaction, Cell Motility
Description:
Caldesmon is an actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Caldesmon Iinteracts with actin, myosin, two molecules of tropomyosin and with calmodulin. Caldesmon also plays an essential role during cellular mitosis and receptor capping.
Alternate Names: Caldesmon, CDM, CALD1, CAD, CDM
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q05682
Antigen: Caldesmon from turkey gizzard.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
