CaMK2a polyclonal, anti-human, mouse, rat, pig, bovine, dog, monkey, xenopus

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Development and Behavior, Nervous and Sensory Systems, Signal Transduction

Description:
CaMK2a (CAMKII alpha, CaM Kinase 2 alpha) is a prominent Ser/Thr kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling complex at the excitatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.

Alternate Names: CaMK2a, Calcium/calmodulin-dependent protein kinase type II alpha chain, CaM-kinase II alpha chain, CaM kinase II subunit alpha, CaMK-II subunit alpha

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q9UQM7

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CaMK2a.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.