CASP1 (p20,Cleaved-Asn120) polyclonal, anti-human

Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Synonyms: CASP1, ICE, IL1BC, P45, caspase-1

Cellular Location: Cytoplasm 

Immunogen:
A synthetic peptide of human CASP1 (p20,Cleaved-Asn120)

Gene Symbol: CASP1 (p20,Cleaved-Asn120)

Gene ID: 834

Swiss prot: P29466

Calculated MW: 45/43/35/30/10kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.