Caspase-10 polyclonal, anti-human, mouse, rat

Protein Family: Peptidases, Enzymes

Pathway and Disease: Cell Growth and Death

Description:
Caspase 10 is involved in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates caspase-3, -4, -6, -7, -8, and -9 and is recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. Caspase-10 participates in the granzyme B apoptotic pathways, and hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Alternate Names: Caspase 10, CASP-10, ICE-like apoptotic protease 4, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, CASP10, MCH4

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500

Accession No.: Q92851

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human caspase-10.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.