Caspase-8 polyclonal, anti-human

Protein Family: Enzymes, Peptidases

Pathway and Disease: Cell Growth and Death, Cancers, Immune System, Neurodegenerative Disorders, Infectious Diseases

Description:
Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 forms an aggregate with FADD called death-inducing signaling complex (DISC). DISC performs caspase-8 proteolytic activation. The active dimeric enzyme is liberated from the DISC and free to activate downstream apoptotic proteases. Defects in caspase-8 are the cause of caspase-8 deficiency (CASP8D). CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs).

Alternate Names: Caspase-8, CASP-8, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, MCH5

Application Notes: E: 1:1,000-1:10,000; WB: 1:200-1:1,000; IHC: 1:50-1:200

Accession No.: Q14790

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human caspase-8.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.