Caspase-9 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Peptidases

Pathway and Disease: Signal Transduction, Cell Growth and Death, Cancers

Description:
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Alternate Names: Caspase-9, CASP-9, ICE-like apoptotic protease 6, ICE-LAP6, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IP: 1:20-1:100

Accession No.: P55211

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Caspase-9.

Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.