Catenin-β (clone ), anti-human, mouse, rat

Background:
β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Alternative Name:
Catenin β, Cateninβ, Catenin beta-1, Beta-catenin, CTNNB1, CTNNB, ORF Names: OK/SW-cl.35, PRO2286

Application Dilution: WB: 1:500-1:5000, ICC: 1:20-1:50, IHC: 1:20-1:200

Specificity: This antibody detects endogenous levels of Catenin-β and does not cross-react with related proteins.

Immunogen:
Recombinant antibody.

MW: ~ 92 kDa

Swis Prot.: P35222

Purification & Purity:
Protein A affinity purified

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.