Cathepsin D (clone CP-D13), anti-human
€362.00
In stock
SKU
251720
Catalog Nr.: 251720
Size: 0.1 mg
Isotype: Mouse IgG2a
Applications: E, WB
Size: 0.1 mg
Isotype: Mouse IgG2a
Applications: E, WB
Protein Family: Enzymes, Peptidases
Pathway and Disease: Signaling Molecules and Interaction
Description:
Cathepsin D is an acid protease active in intracellular protein breakdown. Cathepsin D is involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Cathepsin D consists of a light chain and a heavy chain. Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10), also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. This results in seizures, dementia, visual loss, and/or cerebral atrophy.
Alternate Names: Cathepsin D, CTSD, CPSD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P07339
Antigen: Human liver cathepsin D.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Rouse R et al. 2013.Toxicologic Pathology. doi: 10.1177/0192623313486967. PMID# 23640381.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Cathepsin D is an acid protease active in intracellular protein breakdown. Cathepsin D is involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Cathepsin D consists of a light chain and a heavy chain. Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10), also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. This results in seizures, dementia, visual loss, and/or cerebral atrophy.
Alternate Names: Cathepsin D, CTSD, CPSD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P07339
Antigen: Human liver cathepsin D.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Rouse R et al. 2013.Toxicologic Pathology. doi: 10.1177/0192623313486967. PMID# 23640381.
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