CBX4 polyclonal, anti-human
€347.00
In stock
SKU
251922
Catalog Nr.: 251922
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Signaling Molecules and Interaction, Transcription
Description:
E3 SUMO-protein ligase CBX4 (CBX4) is a protein ligase which facilitates SUMO1 conjugation by UBE2I. CBX4 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; and it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Alternate Names: E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4
Application Notes: E: 1:10,000-1:40,000; WB: 1:200-1:1,000
Accession No.: O00257
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CBX4.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Transcription
Description:
E3 SUMO-protein ligase CBX4 (CBX4) is a protein ligase which facilitates SUMO1 conjugation by UBE2I. CBX4 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; and it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Alternate Names: E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4
Application Notes: E: 1:10,000-1:40,000; WB: 1:200-1:1,000
Accession No.: O00257
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CBX4.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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