CCND1 (clone 3D8), anti-human
€394.00
In stock
SKU
253019
Catalog Nr.: 253019
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signal Transduction, Cell Growth and Death, Cell Communication, Cancers
Description:
CCND1 (Cyclin D1) is a cell-cycle related protein kinase. Complexes with CDK4 and CDK6 serine/threonine protein kinases to impart substrate specificity. Cyclin-D1 is essential for G1/S phase transition. Following DNA damage, Cyclin-D1 is phosphorylated at Thr-286 by MAP kinases, leading to its FBXO31-mediated ubiquitination and subsequent degradation. Chromosomal aberrations of CCND1 lead to various neoplastic and proliferative disorders.
Alternate Names: Cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, BCL-1 oncogene, BCL1, PRAD1, B-cell lymphoma 1 protein, CCND1, Cyl-1
Application Notes: WB: 1:500-1:2000
Accession No.: P25322
Antigen: Purified recombinant fragment of human CCND1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signal Transduction, Cell Growth and Death, Cell Communication, Cancers
Description:
CCND1 (Cyclin D1) is a cell-cycle related protein kinase. Complexes with CDK4 and CDK6 serine/threonine protein kinases to impart substrate specificity. Cyclin-D1 is essential for G1/S phase transition. Following DNA damage, Cyclin-D1 is phosphorylated at Thr-286 by MAP kinases, leading to its FBXO31-mediated ubiquitination and subsequent degradation. Chromosomal aberrations of CCND1 lead to various neoplastic and proliferative disorders.
Alternate Names: Cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, BCL-1 oncogene, BCL1, PRAD1, B-cell lymphoma 1 protein, CCND1, Cyl-1
Application Notes: WB: 1:500-1:2000
Accession No.: P25322
Antigen: Purified recombinant fragment of human CCND1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review