CCP polyclonal, anti-human
€402.00
In stock
SKU
251424
Catalog Nr.: 251424
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cellular Antigens
Pathway and Disease: Immune System
Description:
Citrulline is the deaminated form of arginine. Recently, the detection of citrillunated proteins, specifically keratin, has been of interest in the preliminary diagnosis of rheumatoid arthritis (RA). The epitope of keratin that is recognized by auto-antibodies is cyclic citrulline. Antibodies developed to recognize cyclic citrulline peptide (CCP) have provided earlier RA detection as compared to the historically used rheumatoid factor analysis. This antibody is raised against a peptide derived from human filaggrin cyclized by a disulfide bridge. Filaggrin aggregates intermediate keratin filaments by promoting disulfide bond formation. Filaggrin is modified by citrullination.
Alternate Names: CCP, Cyclic citrullinated peptide, citrulline
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: 372-75-8
Antigen: KLH-conjugated cyclic citrullinated peptide.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System
Description:
Citrulline is the deaminated form of arginine. Recently, the detection of citrillunated proteins, specifically keratin, has been of interest in the preliminary diagnosis of rheumatoid arthritis (RA). The epitope of keratin that is recognized by auto-antibodies is cyclic citrulline. Antibodies developed to recognize cyclic citrulline peptide (CCP) have provided earlier RA detection as compared to the historically used rheumatoid factor analysis. This antibody is raised against a peptide derived from human filaggrin cyclized by a disulfide bridge. Filaggrin aggregates intermediate keratin filaments by promoting disulfide bond formation. Filaggrin is modified by citrullination.
Alternate Names: CCP, Cyclic citrullinated peptide, citrulline
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: 372-75-8
Antigen: KLH-conjugated cyclic citrullinated peptide.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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