CD 8b (clone EBS-CD-007), anti-human

Source:
A BALB/c mouse was immunized with human PBL.
Fusion partner: NS-1.



Specifications:
EBS-CD-007 recognized a protein of 32 kDa, identified as CD8b. The CD8 molecule consists of α and β chains, which are disulphide-linked into heterodimers or homodimers. CD8 is expressed on a T-cell subset (cytotoxic-suppressor T-cells), thymocytes and NK cells. The majority of CD8+ T-cells express CD8 as heterodimer. Some subpopulation of CD8+ T-cells as well as NK-cells may express homodimer. CD8 functions as a co-receptor is concert with TCR for binding the MHC class I/peptide complex. HIV-2 envelope glycoprotein binds CD8 α chain but not β chain.

Species reactivity:
Positive: human.

Applications:
Characterization of leukemia and lymphoma.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin section: ―

Positive control: HuT78 or hPBL. tonsil.

References:
- Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989.
- Parnes JR, Semin Immunol6:221-229(1994).
- Hadi Hossein Nataj Arab et al., Gastroenterol Hepatol Bed Bench. 8(2): 132–139 (2015).