CD109 (clone EBS-CD-046), anti-human, monkey

Source:
A BALB/c mouse was immunized with recombinant human CD109.
Fusion partner: NS-0.



Specifications:
CD109 is a GPI-anchored member of the alpha-2-macroglobulin (A2M) and complement family of proteins. It is expressed on activated T-cells, platelets, hematopoietic stem cells, megakaryocyte precursors, vascular endothelial cells, basal and myoepithelial cells of secretory glands, and squamous cell carcinomas. A 170-180 kDa precursor is autocatalytically reduced to 150 kDa and 120 kDa forms. On keratinocytes CD109 binds TGF-beta and associates with TGF-beta RI and TGF-beta RII, resulting in inhibition of TGF-beta signalling. Polymorphisms of CD109 include the platelet-specific Gov antigen and the blood group ABH antigens. Alloantibodies directed against these antigens result in unsuccessful platelet transfusions, neonatal alloimmune thrombocytopenia, and post-transfusion purpura.

Species reactivity:
Positive: human, monkey.

Applications:
Demonstration of CD109.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +

Positive control: Human platelets, blood vessels.

References:
- Emori M, et al, PLoS One8(12):e84187 (2013)