CD140a (PDGFRA) polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, Protein Kinases

Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Cell Communication, Cancers

Description:
The PDGF receptor type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen) a 170kD protein, binds all three isoforms of PDGF with high affinity; whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity . Both receptors are trans membranous, ligand activated protein tyrosine kinases which phosphorylate a number of important signal transduction proteins that are bound with differential affinities via SH2 domains.

Alternate Names: PDGF-R-A, Alpha-type platelet-derived growth factor receptor, PDGF-R-alpha, CD140 antigen-like family member A, CD140a antigen, CD140a, PDGFRA

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P16234

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PDGF-R-A.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A and immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.