CD140b (PDGFRB) polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, Protein Kinases

Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Cell Communication, Cancers

Description:
The PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity, whereas the PDGF receptor type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen), a 170kD protein, binds all three isoforms of PDGF with high affinity. Both receptors are trans membranous, ligand activated protein tyrosine kinases which phosphorylate a number of important signal transduction proteins that are bound with differential affinities via SH2 domains.

Alternate Names: PDGF-R-B, Beta-type platelet-derived growth factor receptor, PDGF-R-beta, CD140 antigen-like family member B, CD140b, PDGFRB

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P09619

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDGF-R-B.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.