CD141 (Thrombomodulin) polyclonal, anti-human, mouse, rat, dog, bovine
€362.00
In stock
SKU
251178
Catalog Nr.: 251178
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cellular Antigens, Proteoglycans
Pathway and Disease: Immune System
Description:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in thrombomodulin are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD). THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.
Alternate Names: TM, Thrombomodulin, Fetomodulin, CD141, THBD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P07204
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of mouse thrombomodulin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System
Description:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in thrombomodulin are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD). THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.
Alternate Names: TM, Thrombomodulin, Fetomodulin, CD141, THBD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P07204
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of mouse thrombomodulin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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