CD146 (clone TEA1/34) PURE, anti-human RUO

This antibody reacts with the CD146 antigen, which is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified. Among peripheral whole blood leucocytes, CD146 expression is not detected, except on a subset of activated T-lymphocytes.

Recomended usage
CD146, clone TEA1/34 is a mAb intended for the identification of MUC18/MCAM antigen, an activation antigen of human T lymphocytes. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/10^6 cells.