CD147 (clone CB-43), anti-human

Source:
A BALB/c mouse was immunized with human native leucocytes.
Fusion partner: NS-0.



Specifications:
CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 is involved in the regulation of matrix remodeling at the epidermal-dermal interface. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes, which are typically increased during tissue degradation and wound healing, are important factors in cancer invasion and metastasis.

Species reactivity:
Positive: human.

Applications:
Demonstration of CD147. Classification of malignant cells.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: -

Positive control: HSB2 cells. renal cell, ovarian carcinoma or melanoma.

References:
- Kirsch AH et. al. Tissue Antigens50(2): 147-52 (1997)