CD147 (clone HI197), anti-human

Protein Family: Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
The CD147 (HI197) antibody recognizes a 50-60 kDa type-I single chain transmembrane glycoprotein named basigin or neurothelin, which is a blood-brain barrier-specific molecule. CD147 antigen has a wide tissue distribution on hematopoietic and non-hematopoietic cells including leukocytes, red blood cells, platelets and endothelial cells. As a potential adhesion molecule, CD147 is involved in embryonic blood-brain barrier development and in integrin-mediated adhesion in brain endothelia.

Alternate Names: CD147, EMMPRIN, Extracellular matrix metalloproteinase inducer, Basigin, Leukocyte activation antigen M6, Collagenase stimulatory factor, 5F7, Tumor cell-derived collagenase stimulatory factor, TCSF, OK blood group antigen, BSG

Application Notes: Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500

Accession No.: P35613

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Tadamitsu K. et al., eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing, Inc., New York.