CD180/RP105 [clone MHR73-11], anti-human, Baboon, Cynomolgus, African Green, Rhesus

Description: CD180 or RP105, BGP95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression depends on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.Localization: membraneDilution: 10-100Positive Control: spleen tissue lysateHIER: citrate pH6.0 or EDTA pH8.0Status: RUO