CD19 (clone HIB19) PE, anti-human
€390.00
In stock
SKU
251063
Catalog Nr.: 251063
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: Cellular Antigens
Pathway and Disease: Immune System
Description:
The CD19 antibody recognizes a 95-kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. CD19 antigen is expressed on normal and neoplastic B cells and also in some bone marrow cells. CD19 expression by B progenitor cells is presumably at late pro-B or early pre-B stages around the time of Ig heavy chain rearrangement. Expression persists during all stages of B cell maturation and is lost on terminal differentiation to plasma cells. CD19 antigen is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets. In normal peripheral blood, 8-20% of lymphocytes express CD19 antigen. CD19 antigen plays a role in regulating B cell proliferation.
Alternate Names: B-lymphocyte antigen CD19, Differentiation antigen CD19, B-lymphocyte surface antigen B4, Leu-12, CD19 antigen, CD19
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P15391
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
[1] Chang C. et al. 2015. IBC Pharmaceuticals, Inc. Patent #: US20140099254.
[2] Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
Pathway and Disease: Immune System
Description:
The CD19 antibody recognizes a 95-kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. CD19 antigen is expressed on normal and neoplastic B cells and also in some bone marrow cells. CD19 expression by B progenitor cells is presumably at late pro-B or early pre-B stages around the time of Ig heavy chain rearrangement. Expression persists during all stages of B cell maturation and is lost on terminal differentiation to plasma cells. CD19 antigen is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets. In normal peripheral blood, 8-20% of lymphocytes express CD19 antigen. CD19 antigen plays a role in regulating B cell proliferation.
Alternate Names: B-lymphocyte antigen CD19, Differentiation antigen CD19, B-lymphocyte surface antigen B4, Leu-12, CD19 antigen, CD19
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P15391
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
[1] Chang C. et al. 2015. IBC Pharmaceuticals, Inc. Patent #: US20140099254.
[2] Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
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