CD193 (CCR-3) polyclonal, anti-human, mouse, rat, bovine
€378.00
In stock
SKU
251536
Catalog Nr.: 251536
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cellular Antigens, Receptors and Channels
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
C-C chemokine receptor type 3 (CCR-3) is a receptor for C-C type chemokine. CCR-3 binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. The activation of CCR-3 subsequently transduces a signal by increasing the intracellular calcium ions level. CCR-3 is an alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR-3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR-3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T cell-mediated mucosal inflammation.
Alternate Names: CCR-3, C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CMKBR3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P51677
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CCR-3.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
C-C chemokine receptor type 3 (CCR-3) is a receptor for C-C type chemokine. CCR-3 binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. The activation of CCR-3 subsequently transduces a signal by increasing the intracellular calcium ions level. CCR-3 is an alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR-3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR-3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T cell-mediated mucosal inflammation.
Alternate Names: CCR-3, C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CMKBR3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P51677
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CCR-3.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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