CD1A polyclonal, anti-human
€388.00
In stock
SKU
BS7814
Background:
The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.
Alternative Name:
CD 1a, CD1, CD1a, CD1A, CD1A Antigen, CD1A antigen, a polypeptide, CD1a molecule, CD1A_HUMAN, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1 alpha 3, epidermal dendritic cell marker CD1a, FCB 6, FCB6, HTA 1, HTA1, hTa1 thymocyte antigen, OTTHUMP00000018907, R 4, R4, T 6, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a,
Application Dilution: WB: 1:500 - 1:2000
Specificity: CD1A polyclonal antibody detects endogenous levels of CD1A protein.
Immunogen:
Recombinant full length Human CD1A.
MW: ~ 37 kDa
Swis Prot.: P06126
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.
Alternative Name:
CD 1a, CD1, CD1a, CD1A, CD1A Antigen, CD1A antigen, a polypeptide, CD1a molecule, CD1A_HUMAN, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1 alpha 3, epidermal dendritic cell marker CD1a, FCB 6, FCB6, HTA 1, HTA1, hTa1 thymocyte antigen, OTTHUMP00000018907, R 4, R4, T 6, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a,
Application Dilution: WB: 1:500 - 1:2000
Specificity: CD1A polyclonal antibody detects endogenous levels of CD1A protein.
Immunogen:
Recombinant full length Human CD1A.
MW: ~ 37 kDa
Swis Prot.: P06126
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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