CD1b (clone 100-1A5), anti-human

Source:
A BALB/c mouse was immunized with stimulated human leucocytes.
Fusion partner: NS-1.



Specifications:
100-1A5 reacts with CD1b, a 44KDa type 1 glycoprotein associated with beta2-microglobulin. It isexpressed on dendritic cells, Langerhans cells, thymocytes and T acute lymphoblastic leukemia cells. CD1, type 1 membrane protein, has structural similarity to the MHC class 1 molecule and has been shown to present lipid antigens for recognition by T lymphocytes. CD1b is also expressed in Langerhans interdigitating cells. 100-1A5 also reacts with pyramidal cells in the brain and was typed at the IVth International CD Workshop.

Species reactivity:
Positive: human

Applications:
Indicate T-cell leukemia.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin section: ―

Positive control: Molt-4 cells, human thymus.

References:
- Knapp et. al., W (1989). Leucocyte typing IV. Oxford University Press.