CD1b (clone RIV12), anti-human

Source:
A BALB/c mouse was immunized with human peripheral lymphocytes.
Fusion partner: P3-X63-Ag8.653.



Specifications:
RIV12 reacts with CD1b, a 44KDa type 1 glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes and T acute lymphoblastic leukemiacells. CD1, type 1 membrane protein, has structural similarity to the MHC class 1 molecule and has been shown to present lipid antigens for recognition by T lymphocytes. CD1b is also expressed in Langerhans interdigitating cells.

Species reactivity:
Positive: human.

Applications:
Characterization of leukemia and lymphoma.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin section: -

Positive control: Molt-4, HD Mar cells, human thymus.

References:
- Leerling et al, RIV Mededelingen (1985)