CD20 (clone HI47), anti-human
€323.00
In stock
SKU
250952
Catalog Nr.: 250952
Size: 0.1 mg
Isotype: mouse IgG3
Applications: E, FC, IHC, B
Size: 0.1 mg
Isotype: mouse IgG3
Applications: E, FC, IHC, B
Protein Family: Cellular Antigens
Pathway and Disease: Cancers, Immune System
Description:
The CD20 (HI47) antibody recognizes a 33-37 kDa type-III non-glycosylated phosphoprotein spanning the cell membrane four times therefore called TM4. CD20 antigen is expressed on pre-B cells, resting/activated B cells and corresponding neoplastic B cells, but is absent from plasma cells. CD20 regulates B lymphocyte activation and proliferation. The antibody also reacts with several dendritic, endothelial, epithelial, activated T cells and macrophages. The antibody stains 8-16% of normal peripheral blood lymphocytes. The CD20 (HI47) Antibody inhibits B lymphocyte activation and proliferation.
Alternate Names: B-lymphocyte antigen CD20, Membrane-spanning 4-domains subfamily A member 1, B-lymphocyte surface antigen B1, Leu-16, Bp35, MS4A1, CD20
Application Notes: Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500
Accession No.: P11836, NP_690605
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Gupta P. et al 2010. Blood. 116(17):3258-67. doi: 10.1182. PMID#20628151. Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias.
[2] Yang XF et al. 1990. Shanghai J. of Immunology. 10(2):65.
[3] Yang XF et al. 1991 Chinese J. Immunology. 7(1): 21.
[4] Knapp W.et al. Eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P:798, 1078 Oxford University Press, New York.
[4] Schlossman S et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P:491, 505, 2003 Oxford University Press, New York.
Pathway and Disease: Cancers, Immune System
Description:
The CD20 (HI47) antibody recognizes a 33-37 kDa type-III non-glycosylated phosphoprotein spanning the cell membrane four times therefore called TM4. CD20 antigen is expressed on pre-B cells, resting/activated B cells and corresponding neoplastic B cells, but is absent from plasma cells. CD20 regulates B lymphocyte activation and proliferation. The antibody also reacts with several dendritic, endothelial, epithelial, activated T cells and macrophages. The antibody stains 8-16% of normal peripheral blood lymphocytes. The CD20 (HI47) Antibody inhibits B lymphocyte activation and proliferation.
Alternate Names: B-lymphocyte antigen CD20, Membrane-spanning 4-domains subfamily A member 1, B-lymphocyte surface antigen B1, Leu-16, Bp35, MS4A1, CD20
Application Notes: Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500
Accession No.: P11836, NP_690605
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Gupta P. et al 2010. Blood. 116(17):3258-67. doi: 10.1182. PMID#20628151. Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias.
[2] Yang XF et al. 1990. Shanghai J. of Immunology. 10(2):65.
[3] Yang XF et al. 1991 Chinese J. Immunology. 7(1): 21.
[4] Knapp W.et al. Eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P:798, 1078 Oxford University Press, New York.
[4] Schlossman S et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P:491, 505, 2003 Oxford University Press, New York.
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