CD207 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6881
Background:
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immunostimulatory capacity and play a central role in the initiation and regulation of immune responses . Langerin (CD207) is a Ca(++)-dependent, C-type lectin domain-containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T-cells. Human spleen, lymph node, thymus, liver, lung and heart express langerin protein. The human langerin gene maps to chromosome 2p13 and encodes a 328 amino acid protein .
Alternative Name:
C-type lectin domain family 4 member K, Langerin, CD207, CD207, CLEC4K
Application Dilution: WB: 1:500 - 1:2000
Specificity: CD207 polyclonal antibody detects endogenous levels of CD207 protein.
Immunogen:
Recombinant full length Human CD207.
MW: ~ 37 kDa
Swis Prot.: Q9UJ71
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immunostimulatory capacity and play a central role in the initiation and regulation of immune responses . Langerin (CD207) is a Ca(++)-dependent, C-type lectin domain-containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T-cells. Human spleen, lymph node, thymus, liver, lung and heart express langerin protein. The human langerin gene maps to chromosome 2p13 and encodes a 328 amino acid protein .
Alternative Name:
C-type lectin domain family 4 member K, Langerin, CD207, CD207, CLEC4K
Application Dilution: WB: 1:500 - 1:2000
Specificity: CD207 polyclonal antibody detects endogenous levels of CD207 protein.
Immunogen:
Recombinant full length Human CD207.
MW: ~ 37 kDa
Swis Prot.: Q9UJ71
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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