CD22 (clone HIB22) PE, anti-human
€390.00
In stock
SKU
251067
Catalog Nr.: 251067
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Glycan Binding Proteins
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD22 (HIB22) antibody recognizes a 130-140 kDa type-I transmembrane glycoprotein that is a B cell restricted antigen. CD22 antigen is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B lymphocytes. CD22 expression is increased after activation and lost at the terminal stage of B cell differentiation. Most B cell leukemias and lymphomas also express CD22. It is not expressed in T cells, monocytes and granulocytes. CD22 is an early marker for B-ALL and hairy-cell leukemia diagnostic. CD22 is an adhesion molecule that amplifies the signal of B cell activation. CD22 ligands are CD45RO antigen on T cells and CD75 antigen on B cells participating in the homotopic interaction of T and B cells.
Alternate Names: B-cell receptor CD22, Sialic acid-binding Ig-like lectin 2, Siglec-2, Leu-14, B-lymphocyte cell adhesion molecule, BL-CAM, CD22, SIGLEC2
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P20273, NP_001762
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD22 (HIB22) antibody recognizes a 130-140 kDa type-I transmembrane glycoprotein that is a B cell restricted antigen. CD22 antigen is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B lymphocytes. CD22 expression is increased after activation and lost at the terminal stage of B cell differentiation. Most B cell leukemias and lymphomas also express CD22. It is not expressed in T cells, monocytes and granulocytes. CD22 is an early marker for B-ALL and hairy-cell leukemia diagnostic. CD22 is an adhesion molecule that amplifies the signal of B cell activation. CD22 ligands are CD45RO antigen on T cells and CD75 antigen on B cells participating in the homotopic interaction of T and B cells.
Alternate Names: B-cell receptor CD22, Sialic acid-binding Ig-like lectin 2, Siglec-2, Leu-14, B-lymphocyte cell adhesion molecule, BL-CAM, CD22, SIGLEC2
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P20273, NP_001762
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
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