CD220 (INSR) polyclonal, anti-human, mouse, rat

Protein Family: Cellular Antigens, Enzymes, Protein Kinases, Receptors and Channels

Pathway and Disease: Cell Communication, Endocrine System, Metabolic Disorders, Neurodegenerative Disorders

Description:
INSR binds insulin and has a tyrosine protein kinase activity. The short isoform has a higher affinity for insulin. The receptor mediates the metabolic functions of insulin. The receptor binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Defects in INSR are the cause of insulin resistance.

Alternate Names: Insulin receptor, CD220 antigen, IR, INSR

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P06213

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human INSR alpha.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.