CD235 (Glycophorin A) (clone EBS-CD-060), anti-human

Source:
A BALB/c mouse was immunized with human erythrocytes, treated with neuraminidase (V.cholerae).
Fusion partner: X63.Ag8.653.



Specifications:
EBS-CD-060 reacts with a peptide epitope on the extracellular domain of human Glycophorin A, a 39 kDa sialoglycoprotein, present on red cells and erythroid precursor cells. Glycophorin A is the carrier of blood group M and N specificities, while Glycophorin B carries S and U specificities. Providing a mucin like coat, Glycophorin may play a role in preventing red cell aggregation in the circulation. Glycophorin also acts as receptors for Sendai and Parvovirus.

Species reactivity:
Positive: human. Negative: cow.

Applications:
Blood groups, haematology and virology.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +

Positive control: Erythrocytes.

References:
- Cartron JP et al, Transfus Med Rev 6(2): 63-92 (1992).
- Gahmberg CG et al. Rev Fr Transfus Immunohematol 24(1): 53-73 (1981).
- Wybenga LE et al. Biochemistry,35(29): 9513-8 (1996).
- Rahuel C et al. J Biol Chem 269(52): 32752-8 (1994).
- Thacker TC et al. J Gen Virol 79: 2163-9 (1998)