CD248 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60152
Background:
Tumor endothelial marker 1 (TEM1/endosialin) is a heavily glycosylated, type I transmembrane C-type lectin-like receptor of the Ras superfamily expressed in the vascular endothelium and on fibroblast-like cells in developing organs. Expression of TEM1 largely disappears in adulthood. TEM1 is structurally related to thrombomodulin and complement receptor C1qRp. It consists of three EGF-like domains, a C-type lectin domain and a Sushi domain. TEM1 is highly upregulated in tumor endothelium and is known to function in tumor growth and progression. For this reason TEM1 is a major target in anti-angiogenic tumor therapy. TEM1 may be responsible for concentrating liposomes on the surface of target cells and promoting their fusion with the cell membrane.
Alternative Name:
Endosialin, Tumor endothelial marker 1, CD164L1, TEM1
Application Dilution: WB: 1:500~1:1000
Specificity: CD248 polyclonal antibody detects endogenous levels of Endosialin protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CD248.
MW: ~ 50, 80 kDa
Swis Prot.: Q9HCU0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tumor endothelial marker 1 (TEM1/endosialin) is a heavily glycosylated, type I transmembrane C-type lectin-like receptor of the Ras superfamily expressed in the vascular endothelium and on fibroblast-like cells in developing organs. Expression of TEM1 largely disappears in adulthood. TEM1 is structurally related to thrombomodulin and complement receptor C1qRp. It consists of three EGF-like domains, a C-type lectin domain and a Sushi domain. TEM1 is highly upregulated in tumor endothelium and is known to function in tumor growth and progression. For this reason TEM1 is a major target in anti-angiogenic tumor therapy. TEM1 may be responsible for concentrating liposomes on the surface of target cells and promoting their fusion with the cell membrane.
Alternative Name:
Endosialin, Tumor endothelial marker 1, CD164L1, TEM1
Application Dilution: WB: 1:500~1:1000
Specificity: CD248 polyclonal antibody detects endogenous levels of Endosialin protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CD248.
MW: ~ 50, 80 kDa
Swis Prot.: Q9HCU0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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