CD274 polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens

Pathway and Disease: Signaling Molecules and Interaction

Description:
CD274 is involved in the costimulatory signal transduction cascade which is essential for T-cell proliferation. CD274 is also involved in the production of IL-10 and interferon gamma. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

Alternate Names: B7-H1, PDL1, CD274, Programmed death ligand 1, Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, B7 homolog 1, B7H1, PDCD1L1, PDCD1LG1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q9NZQ7

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD274.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.