CD279 (PD-1) (clone 7A11B1), anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Immune System, Signal Transduction

Description:
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Alternate Names: PD-1, Programmed cell death 1, PDCD-1, CD279

Application Notes: E: 1:500-1:1,000; WB: 1:500-1:1,000; IHC: 1:100-1:500; IF: 1:20-1:100

Accession No.: Q02242

Antigen: 150 amino acid recombinant protein from N-term moiety of mouse PD-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.