CD282 (TLR2) polyclonal, anti-human, mouse, rat, pig, bovine
€378.00
In stock
SKU
251110
Catalog Nr.: 251110
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cellular Antigens, Receptors and Channels
Pathway and Disease: Immune System, Infectious Diseases, Signaling Molecules and Interaction
Description:
Toll-like receptor family (TLR) has a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMP) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Toll-line receptor 2 (TLR2) cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 acts via MYD88 and TRAF6 to lead to NFkB activation, cytokine secretion and inflammatory response. TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, in lymph node and in spleen. Genetic variations in TLR2 are associated with susceptibility to leprosy, due to Mycobacterium leprae infection.
Alternate Names: Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: O60603
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TLR2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Gomes FC et al. 2016. Andrology. 4(3): 473-80. PMID 27011054
[2] Garcia PV et al. 2016. BMC Cancer. 16:42. PMID 27389279
[3] Garcia PV. et al. 2015. Int J Clin Exp Pathol. 8(5): 4427-43. PMID 26191134
[4] Stopiglia R et al. 2015. J Cancer Therapy. 6: 129-140.
[5] Femia A et al. 2012. PLoS ONE 7(1):e29918. PMID 22242189.
[6] Kakuta Y et al. Transplant International. 24(5): 514-522. PMID 21291499.
[7] Hua F et al. 2011. Journal of Neuroinflammation. 8: 8-42. PMID 21549006.
Pathway and Disease: Immune System, Infectious Diseases, Signaling Molecules and Interaction
Description:
Toll-like receptor family (TLR) has a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMP) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Toll-line receptor 2 (TLR2) cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 acts via MYD88 and TRAF6 to lead to NFkB activation, cytokine secretion and inflammatory response. TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, in lymph node and in spleen. Genetic variations in TLR2 are associated with susceptibility to leprosy, due to Mycobacterium leprae infection.
Alternate Names: Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: O60603
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TLR2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Gomes FC et al. 2016. Andrology. 4(3): 473-80. PMID 27011054
[2] Garcia PV et al. 2016. BMC Cancer. 16:42. PMID 27389279
[3] Garcia PV. et al. 2015. Int J Clin Exp Pathol. 8(5): 4427-43. PMID 26191134
[4] Stopiglia R et al. 2015. J Cancer Therapy. 6: 129-140.
[5] Femia A et al. 2012. PLoS ONE 7(1):e29918. PMID 22242189.
[6] Kakuta Y et al. Transplant International. 24(5): 514-522. PMID 21291499.
[7] Hua F et al. 2011. Journal of Neuroinflammation. 8: 8-42. PMID 21549006.
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