CD29 (clone HI29a) PE, anti-human

Protein Family: Cell Adhesion Molecules, Receptors and Channels

Pathway and Disease: Cancers, Cell Motility, Signaling Molecules and Interaction

Description:
CD29 antibody recognizes the 130-kDa transmembrane glycoprotein integrin β1 subunit which is the common β1 chain of the very late antigen (VLA) forming a non-covalent heterodimeric complex with several integrins α subunits that are receptors for extracellular matrix proteins such as collagen, fibronectin and osteopontin. CD29 has a broad tissue distribution including lymphocytes, monocytes, platelets, fibroblasts, and endothelial cells, whereas it is weakly expressed in granulocytes and absent in erythrocytes. CD29 is an important adhesion molecule involved in cell-cell and cell-extracellular matrix interactions. CD29 plays a critical role in the functional activity of lymphocytes by influencing cellular migration patterns as well as by transducing intracellular signals that influence lymphocyte function.

Alternate Names: Integrin beta-1, Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, CD29 antigen, ITGB1, FNRB, MDF2, MSK12

Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. IF: 1:200-1:1,000

Accession No.: P05556

Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.