CD295 (Leptin Receptor) (Goat) polyclonal, anti-sheep, goat

Protein Family: Cellular Antigens, Receptors and Channels

Pathway and Disease: Signal Transduction; Signaling Molecules and Interaction; Endocrine System

Description:
The Leptin receptor (OB receptor, OBR) is the receptor for the obesity factor (leptin). The Leptin Receptor is involved in the regulation of fat metabolism and in lymphopoiesis. The Leptin receptor is closely related to the gp130 signal transducing component common to the IL-6, LIF, CNTF and G-CSF receptors. The Leptin receptor has multiple isoforms (A-E) with isoform B (OBRb) being the long single-pass type I membrane receptor, isoform C (OBRa) carrying a short cytoplasmic domain, and isoform E a shorter secreted form. This antibody is against the short form (isoform C).

Alternate Names: Leptin receptor, LEP-R, OB receptor, OB-R, HuB219, CD295 antigen, LEPR, DB, OBR

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P48357

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of goat Leptin Receptor (isoform C).

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.