CD295 (Leptin Receptor) (long) polyclonal, anti-human, mouse, rat, pig, bovine, dog, horse
€378.00
In stock
SKU
250739
Catalog Nr.: 250739
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cellular Antigens, Receptors and Channels
Pathway and Disease: Signal Transduction; Signaling Molecules and Interaction; Endocrine System
Description:
The Leptin receptor (OB receptor, OBR) is the receptor for the obesity factor (leptin). The Leptin Receptor is involved in the regulation of fat metabolism and in lymphopoiesis. The Leptin receptor is closely related to the gp130 signal transducing component common to the IL-6, LIF, CNTF and G-CSF receptors. The Leptin receptor has multiple isoforms (A-E) with isoform B (OBRb) being the long single-pass type I membrane receptor, isoform C (OBRa) carrying a short cytoplasmic domain, and isoform E a shorter secreted form. This antibody is specific for the long form (isoform B).
Alternate Names: Leptin receptor, LEP-R, OB receptor, OB-R, HuB219, CD295 antigen, LEPR, DB, OBR
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500
Accession No.: P48357
Antigen: KLH-conjugated synthetic peptide encompassing a sequence unique to isoform B (long form) of human Leptin Receptor.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Bigford G et al. 2012. PLoS One. 7(7): e41073. PMID 22815920.
[2] Connor K et al. 2010. J Dev Orig Health Dis. 1(4): 245-54. PMID 25141872.
Pathway and Disease: Signal Transduction; Signaling Molecules and Interaction; Endocrine System
Description:
The Leptin receptor (OB receptor, OBR) is the receptor for the obesity factor (leptin). The Leptin Receptor is involved in the regulation of fat metabolism and in lymphopoiesis. The Leptin receptor is closely related to the gp130 signal transducing component common to the IL-6, LIF, CNTF and G-CSF receptors. The Leptin receptor has multiple isoforms (A-E) with isoform B (OBRb) being the long single-pass type I membrane receptor, isoform C (OBRa) carrying a short cytoplasmic domain, and isoform E a shorter secreted form. This antibody is specific for the long form (isoform B).
Alternate Names: Leptin receptor, LEP-R, OB receptor, OB-R, HuB219, CD295 antigen, LEPR, DB, OBR
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500
Accession No.: P48357
Antigen: KLH-conjugated synthetic peptide encompassing a sequence unique to isoform B (long form) of human Leptin Receptor.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Bigford G et al. 2012. PLoS One. 7(7): e41073. PMID 22815920.
[2] Connor K et al. 2010. J Dev Orig Health Dis. 1(4): 245-54. PMID 25141872.
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