CD2AP polyclonal, anti-human, mouse, rat
€362.00
In stock
SKU
251169
Catalog Nr.: 251169
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Infectious Diseases
Description:
CD2-associated protein (CD2AP) is an adapter protein between membrane proteins and the actin cytoskeleton. CD2AP plays a role in receptor clustering and cytoskeletal polarity in the junction between T-cells and antigen-presenting cells. CD2AP anchors the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis. Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3), a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema.
Alternate Names: CD2AP, CD2-associated protein, Cas ligand with multiple SH3 domains, Adapter protein CMS
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q9Y5K6
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD2AP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Infectious Diseases
Description:
CD2-associated protein (CD2AP) is an adapter protein between membrane proteins and the actin cytoskeleton. CD2AP plays a role in receptor clustering and cytoskeletal polarity in the junction between T-cells and antigen-presenting cells. CD2AP anchors the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis. Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3), a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema.
Alternate Names: CD2AP, CD2-associated protein, Cas ligand with multiple SH3 domains, Adapter protein CMS
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q9Y5K6
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD2AP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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