CD31 (N-term) polyclonal, anti-human, mouse, rat, bovine, pig, sheep
€378.00
In stock
SKU
250589
Catalog Nr.: 250589
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cell Adhesion Molecules, Enzymes, CAM Ligands, Cellular antigens, Glycan binding proteins
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.
Alternate Names: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, CPIIA', CD31 antigen, PECAM1
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P16284
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD31.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wang ZD et al. 2015. Am J Cancer Res. 5(11): 3339-49. PMID 26807315.
[2] Szulcek R et al. 2016. Am J Respir Crit Care Med. 193(12): 1410-20.
[3] Kim MN et al. 2015. Cancer Chemother Pharmacol. 76(2): 257-67. PMID 26037205.
[4] Lips K et al. 2013. PLoS ONE. 8(10):e77259. PMID 24130867.
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.
Alternate Names: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, CPIIA', CD31 antigen, PECAM1
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P16284
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD31.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wang ZD et al. 2015. Am J Cancer Res. 5(11): 3339-49. PMID 26807315.
[2] Szulcek R et al. 2016. Am J Respir Crit Care Med. 193(12): 1410-20.
[3] Kim MN et al. 2015. Cancer Chemother Pharmacol. 76(2): 257-67. PMID 26037205.
[4] Lips K et al. 2013. PLoS ONE. 8(10):e77259. PMID 24130867.
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